Alzheimer’s Disease and HLA-A2: Linking Neurodegenerative to Immune Processes through an In Silico Approach

Table 2

Genes with a contribution higher than 0.1% to the similarity between AD and HLA-A.

Gene	Percentage	Weight in AD	Weight in HLA-A
HLA-A	38.870
APLP2	21.170
APP	17.115
HLA-DRB1	5.576
CD8A	3.116
ICAM1	2.115
HLA-B	1.904
HLA-C	1.721
CD4	0.611
IFNG	0.391
HFE	0.223
IL1B	0.176
IL2	0.170
TYR	0.165
WT1	0.147
SELL	0.138
ITGB2	0.135
ITGAL	0.128
CD80	0.124
CD86	0.123
SELP	0.113

Cohesion score value 0.02.