Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies

Table 4

Selected miRNAs targeting transcription factors.

Natural agent	miRNA	Regulation	Target(s) and function(s)	Cancer type	Reference
Curcumin	miR-22	Up	miRNA inhibition upregulates SP1 and ESR1 expression and vice versa	Pancreatic	[78]
	miR-27a, miR-20a, miR-17-5p	Down	Targets ZBTB4 and ZBTB10	Colon	[79]
Resveratrol	miR-34a	Up	Targets E2F3	Colon	[80]
	miR-520h	Down	Inhibits cell migration and invasion, decreases levels of FOXC2	Lung	[81]
	miR-663	Up	Targets JunB and JunD; decreases miR-155	Leukemia	[82]
DIM	miR-200	Down	Targets ZEB1; downregulates ZEB1, slug, and vimentin; upregulates E-cadherin	Pancreatic	[83]