Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder

Figure 5

Summarised results of immunofluorescence, Western blotting, and scanning electron microscopy in normal human urothelium and in low and high grade papillary urothelial carcinomas. Uroplakin UPIIIa expression and apical surface appearance indicate differentiation stages of urothelial cells. P2X3, P2X5, TRPV1, and TRPV4 expressions are illustrated and their correlations with differentiation stage of urothelial cells are presented. Black squares indicate high protein expression, dashed squares denote moderate protein expression, and white squares represent no protein expression.