Inhibition of MMP-2 Expression with siRNA Increases Baseline Cardiomyocyte Contractility and Protects against Simulated Ischemic Reperfusion Injury

Figure 6

Effect of MMP-2 siRNA transfection on cardiomyocyte contractility (a) and MLC1 and MLC2 in cardiomyocytes subjected to I/R. As a protein loading control the tubulin level was measured. Control cells were transfected with scrambled siRNA. 𝑛=11 per group for contractility measurement and 𝑛=4 for measurement of protein levels. ^∗𝑃<0.05 versus control, ^#𝑃<0.05 versus I/R.

(a)

(b)