Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment
Figure 4
HAS overexpression induces loss of plasma membrane E-cadherin and accumulation of cytoplasmic β-catenin, and removal of hyaluronan translocates them to the plasma membrane. Vehicle- and PEGPH20- (2 doses; 4,500 μg/kg; /group) treated tumors were stained for E-cadherin (a) and β-catenin (b). E-cadherin was also localized in pancreatic tumors from a KPC mouse model after 0, 8, 24, and 72 h treatment with PEGPH20 (c; /group) and in human NSCLC biopsies before and after PEGPH20 therapy (d). Scale bar in (a–d) is 250 μm. Insets in (a–d) represent 3x magnification of the original micrograph.
