Antitumor and Antiangiogenic Activities of Curcumin in Cervical Cancer Xenografts in Nude Mice

<table>(a) Immunohistochemical staining for CD31 in Control + vehicle group (A), Control + CUR (B), CaSki + vehicle group (C), CaSki + CUR500 group (D), CaSki + CUR1000 group (E), and CaSki + CUR1500 group (F). Bar = 10 <i>μ</i>m, 200x. (b) Microvascular density (numbers/0.4 mm<sup>2</sup>) (mean ± SEM). <svg height="13.95" id="M21" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 74.474998 13.95" width="74.474998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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<g transform="matrix(.017,-0,0,-.017,7.675,13.688)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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q0 -76 10 -138.5t37 -107.5t69 -45q32 0 55.5 25t35.5 68.5t17.5 91.5t5.5 105t-5.5 105.5t-18 92t-36 68t-56.5 24.5z" id="x30"></path></g><g transform="matrix(.017,-0,0,-.017,58.093,13.688)"><path d="M241 635q53 0 94 -28.5t63.5 -76t33.5 -102.5t11 -116q0 -58 -11 -112.5t-34 -103.5t-63.5 -78.5t-94.5 -29.5t-95 28t-64.5 75t-34.5 102.5t-11 118.5q0 58 11.5 112.5t34.5 103t64.5 78t95.5 29.5zM238 602q-32 0 -55.5 -25t-35.5 -68t-17.5 -91t-5.5 -105
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</svg> versus Control + vehicle group, <svg height="16.275" id="M22" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 76.9375 16.275" width="76.9375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,.062,7.85)"><path d="M750 301l-353 -353l-353 353l353 353z" id="x25C6"></path></g>
<g transform="matrix(.017,-0,0,-.017,10.138,16)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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q0 -76 10 -138.5t37 -107.5t69 -45q32 0 55.5 25t35.5 68.5t17.5 91.5t5.5 105t-5.5 105.5t-18 92t-36 68t-56.5 24.5z" id="x30"></path></g><g transform="matrix(.017,-0,0,-.017,48.521,16)"><path d="M113 -12q-24 0 -39.5 16t-15.5 42q0 24 16 40.5t40 16.5t40 -16.5t16 -40.5q0 -26 -16 -42t-41 -16z" id="x2E"></path></g><g transform="matrix(.017,-0,0,-.017,52.396,16)"><path d="M241 635q53 0 94 -28.5t63.5 -76t33.5 -102.5t11 -116q0 -58 -11 -112.5t-34 -103.5t-63.5 -78.5t-94.5 -29.5t-95 28t-64.5 75t-34.5 102.5t-11 118.5q0 58 11.5 112.5t34.5 103t64.5 78t95.5 29.5zM238 602q-32 0 -55.5 -25t-35.5 -68t-17.5 -91t-5.5 -105
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</svg> versus CaSki + vehicle group and CaSki + CUR500 group, and <svg height="16.075001" id="M23" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 67.875 16.075001" width="67.875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,.062,7.65)"><path d="M684 161q0 -65 -39.5 -112.5t-98.5 -47.5q-49 0 -88 29t-53 75h-19q2 -19 13 -92t13 -97q-33 -13 -84 -17l-14 10q0 3 19 196h-20q-14 -46 -53 -75t-88 -29q-59 0 -98.5 47.5t-39.5 112.5q0 64 39.5 111.5t98.5 47.5q46 0 85 -21l17 28q-53 67 -53 151q0 65 39.5 112.5
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<g transform="matrix(.017,-0,0,-.017,9.225,15.812)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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l-26 -65h-233z" id="x35"></path></g>
</svg> versus CaSki + CUR1,000 group.</table>

BioMed Research International

fig3

Figure 3

Figure 3: Antitumor and Antiangiogenic Activities of Curcumin in Cervical Cancer Xenografts in Nude Mice 