Advance of Molecular Imaging Technology and Targeted Imaging Agent in Imaging and Therapy

Figure 6

T1-weighted multiple slice multiple echo weighted MRI of nude mice bearing A549 tumors before and 0.5, 2, and 6 h after intraperitoneal injection. Tumors (arrows) all showed different enhancement level at 0.5 h, but in Gd-DOTA-ASON (upper line), the enhancement remained at 6 h, while Gd-DTPA (middle line) decreased obviously from 2 h (repetition time, 561 ms, echo time, 14 ms, and field of view, 4 cm); Gd-DOTA-SON (lower line) showed a similar trend to that of Gd-DOTA-ASON but with lower enhancement (adopted from Ren et al. [61]).