Prevalence of Ischemic Heart Disease and Management of Coronary Risk in Daily Clinical Practice: Results from a Mediterranean Cohort of HIV-Infected Patients

Table 2

Changes in modifiable cardiovascular risk factors and Framingham score at the three time points of the study in the 81 included patients.

Laboratory data	Before starting ARV	At the time of the coronary event^a	Last observation^b	^c value; (baseline to coronary event)	^d value; (event to present)
CD4, cell/µL (median [IQR])	224 (89, 422)	497 (384, 776)	559 (375, 767)	0.000	0.201
HIV-RNA, log (median [IQR])	4.6 (3.6, 5.3)	1.8 (1.4, 2.7)	1.4 (1.3, 1.7)	0.000	0.000
Serum total cholesterol, mg/dL (median [IQR])	185 (154, 213)	182 (152, 230)	174 (147, 205)	0.402	0.025
Serum HDL-cholesterol, mg/dL (median [IQR])	41 (30, 43)	42 (35, 52)	45 (33, 53)	0.155	0.974
Serum LDL-cholesterol, mg/dL (median [IQR])	102 (97, 189)	104 (98, 194)	95 (86, 124)	0.305	0.004
CT/HDL-cholesterol ratio mmol/L	4.3 (3.8, 5.6)	4.1 (3.1, 5.8)	4 (3.1, 5.2)	0.110	0.339
Serum triglycerides, mg/dL (median [IQR])	151 (106, 204)	168 (106, 248)	142 (95, 204)	0.778	0.111
Glycemia, mg/dL (median [IQR])	90 (85, 103)	97 (88, 108)	95 (88, 108)	0.140	0.299
Glomerular filtration rate, mL/min (median [IQR])	60 (60, 60)	60 (60, 60)	60 (60, 60)	0.317	0.317
Serum total cholesterol >200 mg/dL (, %)	18 (49)	29 (45)	25 (35.2)	0.265	0.738
Serum HDL-cholesterol <40 mg/dL (, %)	73 (90)	21 (44)	25 (39.7)	0.001	1.000
Serum LDL-cholesterol >100 mg/dL (, %)	7 (46)	17 (45)	25 (41%)	—	0.103
Serum triglycerides >200 mg/dL (, %)	15 (41)	30 (37)	26 (32.1)	0.022	0.238
Serum triglycerides >500 mg/dL (, %)	1 (2.7)	4 (6.3)	3 (4.1)	0.118	0.193
Glycemia >110 mg/dL (, %)	5 (15)	15 (23)	17 (24.3)	0.001	0.52
Framingham <10% (low) (, %)	2 (50)	3 (25)	11 (44)	—	—
Framingham 10%–20% (moderate) (, %)	2 (50)	8 (67)	8 (32)	—	—
Framingham >20% (high) (, %)	—	1 (8)	6 (24)	—	—

^aMedian time (IQR) from starting antiretroviral treatment until the coronary event: 8 (5; 12) years; ^bmedian time (IQR) from the coronary event until the last follow-up visit (June 2011): 7 (4; 11) years.
^c value denotes change from baseline to the time of the coronary event; ^d value denotes change from the coronary event to the last follow-up visit.
CT: total cholesterol; HDL: high-density lipoprotein; LDL: low-density lipoprotein.