Impact of Gentamicin Coadministration along with High Fructose Feeding on Progression of Renal Failure and Metabolic Syndrome in Sprague-Dawley Rats
Table 2
Metabolic study parameters.
Parameter
Time
Control
F
F2
FG
G
Percent of weekly increment in body weight
W1
3.3 ± 0.26
4.2 ± 0.39
4.3 ± 0.34*
4.3 ± 0.34*
3.6 ± 0.31
W2
3.6 ± 0.28
4.4 ± 0.31*
4.7 ± 0.27*
4.7 ± 0.27*
3.0 ± 0.34
W3
3.7 ± 0.29
4.3 ± 0.33*
5.1 ± 0.23
4.5 ± 0.26
3.1 ± 0.29
Energy uptake Kcal/day/100 g (BW)
W1
23 ± 1.4
26 ± 1.2
26 ± 1.2
26 ± 1.2
23 ± 1.4
W2
21 ± 1.3
28 ± 1.6
33.2 ± 1.5@
32.2 ± 1.4@
W3
20 ± 0.9
27 ± 1.6
35.1 ± 1.9*
33.9 ± 1.7*
19 ± 1.2
Energy taken from fructose Kcal/day/100 g (BW)
W1
0
9.31 ± 0.39
10.18 ± 0.38
10.18 ± 0.38
0
W2
0
8.92 ± 0.38
14.64 ± 0.68‡
15.24 ± 0.68‡
0
W3
0
8.78 ± 0.26
15.25 ± 0.54‡
16.15 ± 0.54‡
0
Water uptake μL/min
W1
15.2 ± 1
12.8 ± 0.6
12.4 ± 0.53
11.4 ± 0.48
15.3 ± 1
W2
14.3 ± 1.2
13.6 ± 0.8
13.4.4 ± 1.93
21.6 ± 2.95
W3
15.4 ± 1.1
12.4 ± 0.65
11.1 ± 1.8
UFR μL/min/100 g (BW)
W1
2.18 ± 0.2
1.70 ± 0.1
1.53 ± 0.1
1.44 ± 0.1*
—
W2
2.09 ± 0.18
1.62 ± 0.10$
1.49 ± 0.12$
4.30 ± 0.60
W3
2.16 ± 0.12
1.55 ± 0.08$
1.43 ± 0.06*$
4.06 ± 0.27*
Percentage of increment of body weight was performed weakly while calories and water uptake and urine flow rate were measured in the 1st, 2nd, and 3rd weeks of gentamicin treatment which correspond to the last 3 weeks of the high fructose water treatment period. Results are expressed in mean ± SEM. *, ‡, #, $, and @ indicate statistical significance as compared to control, F, F2, FG, and G groups, respectively ().
