Review Article

Digging Up the Human Genome: Current Progress in Deciphering Adverse Drug Reactions

Table 2

Genetic associations of HLA alleles with severe ADRs.

DrugHLA alleleADREthnic populationReference

AbacavirB*5701HSSCaucasian[51, 52]

AllopurinolB*5801SJS/TEN/HSSHan Chinese, Thai, Japanese,[5356]
European

AminopenicillinsA*2, DRw52DHSItalian[57]

Amoxicillin-clavulanateA*0201DILICaucasian[58]
DQB1*0602

CarbamazepineB*1502SJS/TENHan Chinese, Thai, Indian[5962]
B*1511Japanese[63]
B*5901Japanese[64]
A*3101HSSHan Chinese, Japanese,[6567]
European

DapsoneB*1301HSSHan Chinese[68]

FlucloxacillinB*5701DILICaucasian[69]

LamotrigineB*1502, B*38SJS/TENHan Chinese[55, 70, 71]
B*5801, A*6801,European
Cw*0718,
DQB1*0609,
DRB1*1301

LumiracoxibDRB1*1501DILIMultiple populations[72]
DQB1*0602
DRB5*0101
DQA1*0102

MethazolamideB*5901, CW*0102SJS/TENKorean, Japanese[73]

NevirapineB*3505DHSThai[74]
DRB10101DHSAustralian[75]

OxicamB*73, A*2, B*12SJS/TENEuropean[55, 71]

OxcarbazepineB*1502SJS/TENHan Chinese[70]

PhenytoinB*1502SJS/TENHan Chinese, Thai[59, 70]

SulfamethoxazoleB*38SJS/TENEuropean[55]

HLA: human leukocyte antigen; HSS: hypersensitivity syndrome; SJS/TEN: Stevens-Johnson syndrome/toxic epidermal necrolysis; DHS: delayed-type hypersensitivity reaction; DILI: drug-induced liver injury.