Acknowledged Signatures of Matrix Metalloproteinases in Takayasu’s Arteritis

Table 1

Summary of the various MMPs and TIMPs and alterations in their levels in subjects with Takayasu’s arteritis.

Subgroup	MMPs/TIMPs	Observations	Reference
Collagenases	MMP-1 (collagenase-1)	N.S	[17]
		TA > C, A > R (mRNA)	[44]
	MMP-8 (collagenase-2)	—	—
	MMP-13 (collagenase-3)	—	—
	MMP-18 (collagenase-4)	—	—
Gelatinases	MMP-2 (gelatinase-A)	N.S	[53]
		TA > C, A > R (Activity)	[14]
	MMP-9 (gelatinase-B)	A > C	[46]
		TA > C	[17]
		TA > C; A > R	[47]
		A > R > C	[53]
		TA > C, A > R (mRNA)	[44]
		TA > C, A > R (Activity)
Stromelysins	MMP-3 (stromelysin 1)	A > C	[46]
		N.S	[17]
		TA > C	[47]
		N.S	[53]
		TA > C, A > R (mRNA)	[44]
	MMP-10 (stromelysin 2)	—	—
	MMP-11 (stromelysin 3)	—	—
Matrilysins	MMP-7 (matrilysin-1)	—	—
	MMP-26 (matrilysin-2)	—	—
Membrane-type MMPs	MMP-14, MMP-15, MMP-16, MMP-17, MMP-23, MMP-24, and MMP-25	—	—
Other MMPs	MMP-12, MMP-19, MMP-20, MMP-22, and MMP-28	—	—
TIMPs	TIMP1	C > A	[46]
		TA > C, R > C	[17]
		C > TA	[47]
		TA > C, A versus R = N.S (mRNA)	[44]
	TIMP2	—
	TIMP3	—
	TIMP4	—

TA: total TA population; A: active; R: remission; C: controls; N.S: not significant.