Time Sensitivity Factor of Single Pulmonary Nodule: A New Cancer Characteristic Metabolic Parameter by <svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-5.271399pt" id="M1" height="21.1642pt" version="1.1" viewBox="-0.0657574 -15.8928 23.475 21.1642" width="23.475pt"><g transform="matrix(.013,0,0,-0.013,0,-7.899)"><path id="g22-47" d="M415 0V41C335 46 327 62 327 127V635C236 611 161 593 93 583V547L150 544C187 541 192 535 192 483V127C192 59 182 46 102 41V0H415Z"/></g><g transform="matrix(.013,0,0,-0.013,6.347,-7.899)"><path id="g22-54" d="M266 635C142 635 58 556 58 460C58 387 109 338 166 306C138 289 93 263 75 246S32 205 32 157C32 56 117 -12 252 -12C352 -12 479 51 479 179C479 265 416 313 349 350C386 373 404 390 419 404C442 426 452 452 452 479C452 569 377 635 266 635ZM251 590C291 590 342 557 342 473C342 415 320 385 305 371C227 406 176 440 176 504C176 544 202 590 251 590ZM263 33C214 33 155 76 155 169C155 218 179 263 209 285C310 232 354 208 355 138C356 76 318 33 263 33Z"/></g><g transform="matrix(.018,0,0,-0.018,13.399,1.401)"><path id="g13-68" d="M524 497C519 556 514 633 513 650H40V615C113 608 122 601 122 511V142C122 48 113 42 40 35V0H351V35C264 42 256 48 256 142V300H338C427 300 437 292 448 224H484V423H448C437 359 427 350 338 350H256V571C256 604 260 606 295 606H345C401 606 428 599 449 577C466 559 479 529 489 491L524 497Z"/></g></svg>-FDG PET

<table>The boxplot of the average time sensitivity factor (<svg height="11.75" id="M75" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 8.2875004 11.75" width="8.2875004" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.4)"><path d="M457 488l-30 -3q-17 148 -131 148q-53 0 -84.5 -34.5t-31.5 -82.5q0 -42 25.5 -72t74.5 -62l33 -22q63 -42 95 -85t32 -102q0 -84 -67 -137t-163 -53q-58 0 -113 22t-70 43l-4 152l27 4q4 -32 15 -62.5t31 -59.5t53.5 -47t76.5 -18q56 0 92 35t36 96q0 39 -25 70t-78 68
l-31 22q-32 23 -53.5 41.5t-45 57t-23.5 77.5q0 82 58 132.5t156 50.5q46 0 101 -17l18.5 -6t17 -6t8.5 -3q-4 -55 0 -147z" id="x1D446"></path></g>
</svg>) in discriminating the malignant and benign SPNs. Note the clear-cut wide separation between these two groups at around zero value of <svg height="11.75" id="M76" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 8.2875004 11.75" width="8.2875004" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.4)"><path d="M457 488l-30 -3q-17 148 -131 148q-53 0 -84.5 -34.5t-31.5 -82.5q0 -42 25.5 -72t74.5 -62l33 -22q63 -42 95 -85t32 -102q0 -84 -67 -137t-163 -53q-58 0 -113 22t-70 43l-4 152l27 4q4 -32 15 -62.5t31 -59.5t53.5 -47t76.5 -18q56 0 92 35t36 96q0 39 -25 70t-78 68
l-31 22q-32 23 -53.5 41.5t-45 57t-23.5 77.5q0 82 58 132.5t156 50.5q46 0 101 -17l18.5 -6t17 -6t8.5 -3q-4 -55 0 -147z" id="x1D446"></path></g>
</svg> without any outliners as compared to SUV and RI in Figures <a href="../fig1/">1</a> and <a href="../fig2/">2</a>, respectively.</table>

BioMed Research International

fig4

Figure 4

Figure 4: Time Sensitivity Factor of Single Pulmonary Nodule: A New Cancer Characteristic Metabolic Parameter by <svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-5.271399pt" id="M1" height="21.1642pt" version="1.1" viewBox="-0.0657574 -15.8928 23.475 21.1642" width="23.475pt"><g transform="matrix(.013,0,0,-0.013,0,-7.899)"><path id="g22-47" d="M415 0V41C335 46 327 62 327 127V635C236 611 161 593 93 583V547L150 544C187 541 192 535 192 483V127C192 59 182 46 102 41V0H415Z"/></g><g transform="matrix(.013,0,0,-0.013,6.347,-7.899)"><path id="g22-54" d="M266 635C142 635 58 556 58 460C58 387 109 338 166 306C138 289 93 263 75 246S32 205 32 157C32 56 117 -12 252 -12C352 -12 479 51 479 179C479 265 416 313 349 350C386 373 404 390 419 404C442 426 452 452 452 479C452 569 377 635 266 635ZM251 590C291 590 342 557 342 473C342 415 320 385 305 371C227 406 176 440 176 504C176 544 202 590 251 590ZM263 33C214 33 155 76 155 169C155 218 179 263 209 285C310 232 354 208 355 138C356 76 318 33 263 33Z"/></g><g transform="matrix(.018,0,0,-0.018,13.399,1.401)"><path id="g13-68" d="M524 497C519 556 514 633 513 650H40V615C113 608 122 601 122 511V142C122 48 113 42 40 35V0H351V35C264 42 256 48 256 142V300H338C427 300 437 292 448 224H484V423H448C437 359 427 350 338 350H256V571C256 604 260 606 295 606H345C401 606 428 599 449 577C466 559 479 529 489 491L524 497Z"/></g></svg>-FDG PET 

BioMed Research International

Time Sensitivity Factor of Single Pulmonary Nodule: A New Cancer Characteristic Metabolic Parameter by -FDG PET

Figure 4