A Critical Role for ZDHHC2 in Metastasis and Recurrence in Human Hepatocellular Carcinoma

Figure 6

CCK-8 cell proliferation assay and transwell migration and invasion assay were conducted in Bel-7402 without any treatment (BLANK), transiently transfected with negative control vector (NC), and transiently transfected with overexpression vector (ZDHHC2). (a) Overexpression of ZDHHC2 significantly impaired Bel-7402 proliferation (𝑛=3, *𝑃<0.05 compared to BLANK group, **𝑃<0.01 compared to BLANK group, and ^##𝑃<0.01 compared to NC group). (b) Overexpression of ZDHHC2 inhibits the migration and invasion of BEL-7402 cell (𝑛=5, **𝑃<0.01, and ***𝑃<0.001) compared to both BLANK group and NC group. Representative pictures are shown in (c).

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(b)

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