A Critical Role for ZDHHC2 in Metastasis and Recurrence in Human Hepatocellular Carcinoma

Table 1

Clinicopathological correlation with LOH in HCC cases (cohort 1).

Parameters	Genes	LOH/informative case		𝑃 value
Age		≤50 year	>50 year
	ZDHHC2	12/17	5/21	0.004
	TUSC3	10/16	7/18	0.169
	MCPH1	11/17	9/20	0.231
	KIAA1456	10/16	6/15	0.210
Preoperative AFP level		≤400 ng/mL	>400 ng/mL
	ZDHHC2	4/15	13/23	0.070
	TUSC3	5/12	12/22	0.473
	MCPH1	6/14	14/23	0.286
	KIAA1456	5/11	11/20	0.611
Tumor number		Single	Multiple
	ZDHHC2	4/15	13/23	0.070
	TUSC3	5/12	12/22	0.473
	MCPH1	4/14	16/23	0.015
	KIAA1456	4/11	12/20	0.208
Tumor size		≤5 cm	>5 cm
	ZDHHC2	6/23	11/15	0.004
	TUSC3	9/22	8/12	0.151
	MCPH1	9/22	11/15	0.052
	KIAA1456	8/18	8/13	0.347
PVTT		Absent	Present
	ZDHHC2	11/31	6/7	0.031
	TUSC3	14/29	3/5	1.000
	MCPH1	14/30	6/7	0.097
	KIAA1456	11/24	5/7	0.394
Histopathologic grading		Well + moderately	Poorly
	ZDHHC2	5/16	12/22	0.154
	TUSC3	3/11	14/23	0.067
	MCPH1	9/16	11/21	0.815
	KIAA1456	5/14	11/17	0.108

AFP: alpha-fetoprotein; PVTT: portal vein tumor thrombi.