Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure

Table 3

Top three most enriched pathways of genes differentially expressed in human peripheral blood mononuclear cells when exposed to varying doses of ⁶⁰Co radiation according to KEGG pathway enrichment analysis.

Dose (Gy)	KEGG ID	Pathway	value (BH)	Gene symbol
0.5	4610	Complement and coagulation cascades	0.0018	PLAU, F2R
1	1100	Metabolic pathways		48 genes^a
	3013	RNA transport		RANBP2, EIF1AY, EIF4A2, EIF3E, SUMO3, ELAC2, EIF5, EIF1B, NUP98, EIF3H, TACC3, CLNS1A, and SUMO1
	620	Pyruvate metabolism	0.0001	ACAT1, MDH1, ACACB, PKM, DLD, HAGHL, and ACACA
2.5	4010	MAPK signaling pathway		1L1R1, ELK4, MDUSP6, PLA2G5, MAP4K4, MAP3K8, MAP4K3, PPM1A, IL1A, and PRKACB
	4210	Apoptosis	0.0034	1L1R1, 1L1A, PRKACB, and BAX
	4640	Hematopoietic cell lineage	0.0034	1L1R1, CD44, IL1A, and HLA-DRB5
5	4120	Ubiquitin mediated proteolysis	0.0007	ANAPC1, PARK2, CDC27, PML, SKP1, SAE1, SYVN1, and SOCS3
	4650	Natural killer cell mediated cytotoxicity	0.0034	PIK3R3, TNFRSF10, NRAS, PRKCG, IFNAR1, and TNFRSF10
	4080	Neuroactive ligand-receptor interaction	0.0065	HTR7, SSTR5, GABRB2, TAAR9, S1PR2, GHRHR, TAAR5, CCKAR, and VIPR2

The gene identities are given in the Supplementary Material 2 along with the rest of the KEGG pathway enrichment analysis results.