Outer Electrospun Polycaprolactone Shell Induces Massive Foreign Body Reaction and Impairs Axonal Regeneration through 3D Multichannel Chitosan Nerve Guides
Figure 5
Biomaterial structure of CES and COM grafts after explanation. (a) Electron micrograph of a cross-section through a COM graft after 14 days in vivo, displaying only loose connection between the outer PCL shell and the inner chitosan core. (b) HE-stained cross-section demonstrating the dark colored porous chitosan core in the center ensheathed by swollen PCL shell massively infiltrated by cells. (c) Electron micrograph of a cross-section through a COM graft after 13 weeks in vivo, where the chitosan degradation was reduced and the pore structure still visible. (d) Electron micrograph of a cross-section through a CES graft after 13 weeks in vivo, no longer displaying the original core structure and firmly connected to the outer epineurium.
