Outer Electrospun Polycaprolactone Shell Induces Massive Foreign Body Reaction and Impairs Axonal Regeneration through 3D Multichannel Chitosan Nerve Guides

Figure 6

Functional evaluation of nerve regeneration. (a)–(c) Results of the pain perception test (pinch-test) performed weekly on toe III (a), toe IV (b), and toe V (c) are shown. Bars depict the percentage of animals per group with a positive pinch reaction: *intergroup difference to ANT; §intergroup difference to COM graft; ^#intragroup difference to previous week; 𝑃<0.001. (d) Results of the hind limb motor function evaluation by calculation of the static sciatic index (SSI) are presented: •significant intragroup improvement in comparison to 4 weeks postsurgery value; ^ono longer significantly different to presurgery value; 𝑃<0.05--𝑃<0.001.

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