Outer Electrospun Polycaprolactone Shell Induces Massive Foreign Body Reaction and Impairs Axonal Regeneration through 3D Multichannel Chitosan Nerve Guides

Figure 7

Evaluation of motor function recovery. A summary of parameters related to motor recovery evaluated 13 weeks after surgery is depicted. (a) Ratio of the operated hind limb muscle weight to the nonoperated hind limb muscle weight, (b) functional axonal loss from electrophysiological analysis (%), (c) amplitude of the maximum compound muscle action potential (M CMAP) (mV), and (d) ratio of nerve conduction velocity (NCV). Due to high current intensities only four animals of the COM group were subjected to the detailed analysis of electrophysiological properties (M CMAP amplitude). Bars represent mean ± SEM of the given data. Intergroup differences are indicated by *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001.

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