A Higher Frequency of CD4+CXCR5+ T Follicular Helper Cells in Adult Patients with Minimal Change Disease
Figure 5
Altered frequency of TFH cells and levels of sera cytokines in MCD patients following PDN treatment. The percentages of different subsets of TFH cells and the levels of sera cytokines were compared in MCD patients’ pre- and post-PDN treatment. Data are expressed as the mean % or concentrations of individual subjects from three separate experiments ( for a–f). (a) The percentages of CD4+CXCR5+ in the total CD3+CD4+ T cells in individual patients' pre- and post-PDN treatment, (b) the percentage of CD4+CXCR5+PD-1+ TFH cells in total CD3+CD4+ T cells in individual patients’ pre- and post-PDN treatment, (c) the percentage of CD4+CXCR5+ICOS+ TFH cells in total CD3+CD4+ T cells in individual patients’ pre- and post-PDN treatment, and (d–f) the levels of IL-10, IL-4, and IL-21 in individual patients’ pre- and post-PDN treatment. The horizontal lines represent the median values.
