Evidence for the Existence of Triple-Negative Variants in the MCF-7 Breast Cancer Cell Population

Figure 6

Growth inhibitory concentrations for MCF-7 and its sublines exposed to everolimus (EVL) and NVP-BEZ235 (BEZ). IC50 values (50% inhibition of growth) are shown. The highest drug concentration for everolimus is depicted where 50% growth inhibition was not reached. Cells were treated with drugs for 3 days and cell proliferation was measured by the [³H]-thymidine incorporation assay. Bars indicate standard errors in two independent experiments. ^∗Significantly different from MCF-7 parental line (Holm-Sidak test; 𝑃<0.05).