Adenosine Amine Congener as a Cochlear Rescue Agent

Figure 3

ADAC efficacy study. ADAC (200 μg/kg i.p.) was administered as 5 daily injections commencing 12, 24, 48, or 72 hours after traumatic noise exposure, and the outcomes were measured using auditory brainstem responses (ABR) before and 12 days after noise exposure. In the control group, injections of the vehicle solution were administered at the same intervals as ADAC starting 12 hours after noise exposure. Data are expressed as ABR threshold shifts at different frequencies (mean ± SEM; –10) and threshold shifts averaged across all frequencies (8–28 kHz). ; ; versus control, one-way ANOVA with pairwise comparison.