Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer's Drug Leads

Figure 4

Effects of Lipopolysaccharide, green tea, piceatannol, Markhamia platycalyx, and Schotia brachypetala leaves and Schotia brachypetala stalk on mean mouse amyloid beta 42 concentration using ELISA assay. The normal group was injected with saline 0.9% or DMSO i.p. once with nonsignificant results between them. All the other groups were injected with LPS 0.8 mg/kg once to induce Alzheimer’s disease. Five of them were treated starting 1st day after LPS intraperitoneal injection with PCT 2.5 mg/kg or 100 mg/kg/day GT, MP, SBS, or SBL for 6 days. The brains of all the animals in each group were harvested on the 7th day and preserved until amyloid beta 42 concentration was assayed. Statistical analysis was carried out using unpaired 𝑡-test to compare every two groups. Each value represents mean ± standard error of mean. ∗Significantly different from normal at 𝑃<0.05. ∗∗Significantly different from normal at 𝑃<0.01. ∗∗∗Significantly different from normal at 𝑃<0.001. +Significantly different from LPS at 𝑃<0.05. ++Significantly different from LPS at 𝑃<0.01. +++Significantly different from LPS at 𝑃<0.001. LPS: Lipopolysaccharide. GT: green tea extract of Camellia sinensis. PCT: piceatannol. SBS: Schotia brachypetala leaves. SBL: Schotia brachypetala stalk. MP: Markhamia platycalyx. DMSO: dimethyl sulfoxide. Pg/mL: picogram/milliliter. Aβ: amyloid beta. ELISA: enzyme linked immunosorbent assay. i.p.: intraperitoneal injection.