Effects of SCH-23390 in Combination with a Low Dose of 17β-Estradiol on Anxiety-Like Behavior in Ovariectomized Rats

Figure 2

Effects of SKF-38393 (0.1 mg/kg, i.p.) and SCH-23390 (0.1 mg/kg, i.p.) on the anxiety-like behavior in OVX rats and OVX rats treated with low dose of 17β-E₂ in the BWM. The time spent in exploration towards white compartment (a) and the frequency of explorations towards white compartment (b) of experimental groups in the BWM. Columns represent the time spent in exploration towards white compartment (a) as mean ± SEM (in sec) and the frequency of explorations towards white compartment (b) as mean ± SEM. Each group was comprised of 10 rats. *𝑃<0.05 versus control intact rats (control 1); **𝑃<0.05 versus control OVX rats (control 2); ^#𝑃<0.05 versus OVX rats treated with 17β-E₂.

(a)

(b)