Research Article

New Strategies for Evaluation and Analysis of SELEX Experiments

Figure 4

The result of the performed motif search is shown. In the lower part of the figure, the consensus sequences of the 18 discovered groups, which contain the actual motifs, are depicted. This is done in the form of a directed graph showing a substring relation. That means that a consensus sequence is connected to all other sequences, which are substrings of itself. The emerging hierarchy facilitates the understanding and selection of relevant finds. The upper part shows two concrete motifs in the form of weblogos, which have been picked one from each of the top consensus groups and then have been aligned to each other. The height of each column of the two motif weblogo representations corresponds to the motif positions total information according to the scale on the left side. The letters are then sized by their relative frequency within that motif position.
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