High Expression of Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 Predicts Poor Prognosis in Head and Neck Squamous Cell Carcinoma

Table 2

Correlations between LETM1 protein overexpression and clinicopathological features of HNSCC patients.

Clinical features	Number of cases (𝑛)	LETM1 strongly positive cases (%)	𝜒^2	𝑃 value
Gender
Male	113	72 (63.7%)	0.368	0.545
Female	63	43 (68.3%)
Age (years)
≤60	106	67 (63.2%)	0.536	0.466
>60	70	48 (68.6%)
Primary site
Tongue	92	56 (60.9%)	4.133	0.764
Buccal	37	29 (78.4%)
Gingiva	28	19 (67.9%)
Floor of mouth	19	11 (57.9%)
Tumor differentiation
Well	59	33 (55.9%)	5.988	0.016*
Moderately	81	53 (65.4%)
Poorly	36	29 (80.6%)
pT
T1-2	72	42 (58.3%)	0.93	0.334
T3-4	104	53 (50.9%)
Lymph node
N0	43	19 (44.2%)	11.245	0.001**
N+	133	96 (72.2%)
Tumor stage
I-II	53	19 (35.8%)	29.13	0.001**
III-IV	123	96 (78.0%)
Alcohol use
Positive	113	78 (69.0%)	1.89	0.168
Negative	63	37 (58.7%)
Smoking status
Current/former	104	71 (76.0%)	0.963	0.328
Never	72	44 (50.0%)
Chemoradiotherapy
Yes	117	67 (57.3%)	10.052	0.002**
No	59	48 (81.4%)

^∗𝑃<0.05 and ^∗∗𝑃<0.01.