Micronucleated Erythrocytes in Newborn Rats Exposed to Raltegravir Placental Transfer

Table 1

MNE, MNPCE, and PCE frequencies (‰) of the samples analyzed.

Study groups	MNE	MNPCE	PCE
Negative control: sterile water	1.6 ± 0.6	3.8 ± 1.6	358.3 ± 59.6
Dose 1: raltegravir 15 mg/day	1.5 ± 0.4; NS	3.1 ± 1.5; NS	397.6 ± 50.7; NS
Dose 2: raltegravir 30 mg/day	1.6 ± 0.5; NS	3.6 ± 1.9; NS	360.0 ± 66.3; NS
Dose 3: raltegravir 60 mg/day	1.7 ± 0.5; NS	4.2 ± 1.8; NS	354.7 ± 80.0; NS
Positive control: cyclophosphamide 10 mg/kg/day	48.6 ± 16.3; P < 0.0001	92.3 ± 47.4; P < 0.0001	287.4 ± 71.3; P = 0.007

Data (‰) are expressed as mean ± SD; 𝑛=5/group; NS: not significant; MNE: micronucleated erythrocytes/1000 TE; TE: total erythrocytes; MNPCE: micronucleated polychromatic erythrocytes/1000 PCE; PCE: polychromatic erythrocytes/1000 TE. All groups were compared versus the negative control.