Micronucleated Erythrocytes in Newborn Rats Exposed to Raltegravir Placental Transfer

Table 2

Weight and height in newborn rats from mothers treated during pregnancy.

Study groups	Weight (g)	Height (cm)
Negative control: sterile water	6.5 ± 0.3	5.0 ± 0.2
Dose 1: raltegravir 15 mg/day	5.9 ± 0.4; P < 0.0001	4.8 ± 0.2; P = 0.001
Dose 2: raltegravir 30 mg/day	6.1 ± 0.5; P < 0.0001	4.8 ± 0.3; P = 0.009
Dose 3: raltegravir 60 mg/day	6.3 ± 0.5; NS	4.8 ± 0.4; P = 0.002
Positive control: cyclophosphamide 10 mg/kg/day	4.3 ± 0.2; P < 0.0001	4.4 ± 0.2; P < 0.0001

Data are expressed as mean ± SD; 𝑛=5/group; NS: not significant. All groups were compared versus the negative control.