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| First author/year | Spectrum of patients (only information regarding seminoma patients were included) | Consecutive or random selection of patients | Reference standard | Application of reference standard regardless of index test | Enough explanation of the index test to ensure reproducibility | Independent blind comparison between index test and reference standard |
|
| Ganjoo, 1999 [14] | Seminoma patients after primary or salvage chemotherapy | N/A | Follow-up including chest radiograph, tumor markers, physical examination, and CT | Yes | Yes | N/A |
|
| Hain, 2000 [13] | 13 seminoma patients with possible relapse | Yes | Histology or clinical follow-up (minimum of 18 months) | Yes | Yes | N/A |
|
| Spermon, 2002 [12] | 10 seminoma patients after completion of first-line chemotherapy | N/A | Histology in 2 patients and clinical follow-up in 8 patients (serum tumour markers, CT, and the duration of the event-free follow-up) (median of 12 months) | Yes | Yes | Yes |
|
| De Santis, 2004 [11] | Patients with metastatic pure seminoma who had radiographically defined postchemotherapy residual masses | N/A | Histology (11 resected masses) or follow-up (median of 34 months) | Yes | Yes | N/A |
|
| Lewis, 2006 [10] | Patients with residual mass after primary (14 patients) or salvage chemotherapy (10 patients) | N/A | Histology or clinical follow-up | Yes | No | N/A |
|
| Hinz, 2008 [9] | Patients with residual (18 patients) or recurrent (2 patients) after chemotherapy | Yes | Histology | Yes | Yes | Yes (though CT information was available to the readers) |
|
| Bachner, 2012 [7] | Patients with metastatic seminoma and residual masses after chemotherapy | Yes | Histology or follow-up (at least 24 months) | Yes | Yes | Yes |
|
| Siekiera, 2012 [8] | Patients with advanced seminoma after chemotherapy or radiotherapy in their follow-up scheme | N/A | Histology (7 patients) or follow-up | Yes | No | N/A |
|
| Ambrosini, 2014 [6] | Seminoma patients for restaging (16 patients), routine follow-up (18 patients), or suspected relapse (10 patients). | Yes (all patients in a PET center) | Histology or follow-up | No (the treatment of the patients was affected by the PET results) | Yes | N/A |
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