Role of Plasma Membrane Caveolae/Lipid Rafts in VEGF-Induced Redox Signaling in Human Leukemia Cells

Figure 6

Effect of different inhibitors of VEGF/VEGFR-2 interaction on glucose transport in B1647 cells. Cells, control, and serum starved (−HS, “Control dep”) were treated with 20 μM Semaxinib for 2 h, 500 μg/mL Bevacizumab for 30 min, or 5 μM Cav-1 scaffolding domain (CSD) for 2 h, in the presence or absence of 50 ng/mL VEGF; then, glucose uptake was assayed by liquid scintillation counting as described in Section 2. *𝑃<0.05: significantly different from control cells; ^§𝑃<0.05: significantly different from serum deprived control cells (−HS).