Adipokines, Biomarkers of Endothelial Activation, and Metabolic Syndrome in Patients with Ankylosing Spondylitis

Table 1

Effect of an infusion of the anti-TNF-𝛼 monoclonal antibody infliximab on MeS-related biomarkers, biomarkers of endothelial cell activation and inflammation, and adipokines in a series of AS patients undergoing periodic treatment with this drug.

Target	Biologic effect
MeS-related biomarkers	Reduction in serum insulin levels and IR; Improvement of insulin sensitivity; Reduction of RBP-4 serum levels; No significant change on ghrelin serum levels
Biomarkers of endothelial; cell activation and inflammation	Reduction of Angpt-2 serum levels; Reduction of OPN serum levels; No significant change on ADMA and GSN serum levels; No significant reduction on OPG plasma levels
Adipokines	No significant change in the levels of the different adipokines (adiponectin, resistin, leptin, visfatin, and apelin)