Association between Autoimmune Rheumatic Diseases and the Risk of Dementia
Table 2
Dementia risk among sampled patients of different age groups during the 5-year follow-up period from index health care utilization ().
Dementia
Comparison
All
RA
SLE
SS
Total (%)
141 (2.31)
30 (2.48)
20 (3.14)
5 (1.67)
5 (2.89)
Crude HR (95% CI)
1.00
1.10 (0.74–1.63)
1.42 (0.89–2.27)
0.71 (0.29–1.74)
1.31 (0.54–3.20)
value
0.63
0.24
0.46
0.46
Adjusted HR (95% CI)
1.00
1.18 (0.79–1.76)
1.20 (0.75–1.92)
2.86 (1.16–7.05)
0.81 (0.33–1.99)
value
0.41
0.56
0.02
0.64
Age group
<30
7 (0.11)
2 (0.16)
1 (0.16)
1 (0.33)
0 (0.00)
Crude HR (95% CI)
1.00
1.29 (0.81–1.57)
1.22 (0.77–1.96)
2.73 (0.68–10.99)
—
P value
0.56
0.36
0.67
Adjusted HR (95% CI)
1.00
1.23 (0.76–1.61)
1.12 (0.82–2.04)
3.83 (0.89–16.55)
—
P value
0.62
0.53
0.45
30–49
16 (0.26)
4 (0.33)
3 (0.47)
1 (0.33)
0 (0.00)
Crude HR (95% CI)
1.00
1.31 (0.67–1.63)
1.91 (0.86–2.41)
1.62 (0.71–2.32)
—
P value
0.34
0.48
0.67
Adjusted HR (95% CI)
1.00
1.29 (0.73–1.59)
1.87 (0.81–2.39)
1.48 (0.88–2.45)
—
P value
0.62
0.53
0.45
≥50
118 (1.82)
24 (1.80)
16 (2.51)
3 (1.00)
5 (2.89)
Crude HR (95% CI)
1.00
1.08 (0.76–1.52)
1.38 (0.91–2.33)
0.79 (0.34–1.87)
1.52 (0.57–3.75)
P value
0.59
0.27
0.61
0.43
Adjusted HR (95% CI)
1.00
1.21 (0.81–1.77)
1.24 (0.82–1.89)
0.800 (0.34–1.90)
1.79 (0.51–2.03)
P value
0.44
0.47
0.53
0.47
Hazard ratio was calculated by using Cox proportional regression method during the 5-year follow-up period. Adjustments were made for demographic characteristics (age, sex, and the geographical region) and selected comorbidities in patients (diabetes, hyperlipidemia, hypertension, stroke, heart failure, and atrial fibrillation).
