Research Article
The Domain Landscape of Virus-Host Interactomes
Table 3
Distributions of domains and DDIs.
| | Virus | Number of species | Number of genera | Number of families | Number of types | Description |
| | PF00527 | 5 | 3 | 1 | 1 | E7 protein, early protein | | PF00098 | 5 | 3 | 1 | 1 | Zinc knuckle | | PF00511 | 4 | 3 | 1 | 1 | E2 (early) protein, C terminal | | PF00508 | 4 | 3 | 1 | 1 | E2 (early) protein, N terminal | | PF00073 | 3 | 1 | 1 | 1 | Picornavirus capsid protein | | PF00423 | 3 | 2 | 1 | 1 | Haemagglutinin-neuraminidase |
| | Host | Number of species | Number of genera | Number of families | Number of types | Description |
| | PF00069 | 10 | 7 | 6 | 3 | Protein kinase domain | | PF07686 | 7 | 5 | 5 | 3 | Immunoglobulin V-set domain | | PF00018 | 6 | 4 | 3 | 2 | SH3 domain | | PF00129 | 6 | 5 | 3 | 3 | Class I histocompatibility antigen, domains alpha 1 and 2 | | PF02319 | 5 | 3 | 2 | 2 | E2F/DP family winged-helix DNA-binding domain | | PF07716 | 5 | 4 | 2 | 2 | Basic region leucine zipper | | PF07714 | 5 | 4 | 3 | 3 | Protein tyrosine kinase | | PF00076 | 5 | 3 | 3 | 3 | RNA recognition motif | | PF06623 | 4 | 3 | 3 | 3 | MHC_I C-terminus | | PF00134 | 3 | 2 | 2 | 2 | Cyclin, N-terminal domain | | PF00397 | 3 | 3 | 1 | 1 | WW domain | | PF00870 | 3 | 2 | 2 | 2 | P53 DNA-binding domain | | PF00240 | 3 | 2 | 2 | 2 | Ubiquitin family | | PF03066 | 3 | 2 | 2 | 2 | Nucleoplasmin | | PF00017 | 3 | 2 | 1 | 1 | SH2 domain | | PF00170 | 3 | 3 | 3 | 2 | bZIP transcription factor | | PF00605 | 3 | 2 | 2 | 2 | Interferon regulatory factor transcription factor |
| | Virus-host DDI | Number of species | Number of genera | Number of families | Number of types | Number of intrahosts |
| | PF00527-PF02319 | 4 | 2 | 1 | 1 | 0 | | PF00508-PF07716 | 4 | 3 | 1 | 1 | 0 | | PF00511-PF07716 | 4 | 3 | 1 | 1 | 0 | | PF00098-PF00397 | 3 | 3 | 1 | 1 | 1 | | PF00098-PF00069 | 3 | 1 | 1 | 1 | 0 |
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