The Domain Landscape of Virus-Host Interactomes

Table 5

Top 10 hub and bottleneck domains.

Pfam	Degree	Description	Pfam	Betweenness centrality	Description
PF00069	464	Protein kinase domain	PF00069	0.136	Protein kinase domain
PF00400	214	WD domain, G-beta repeat	PF00400	0.035	WD domain, G-beta repeat
PF00076	186	RNA recognition motif (RNP domain)	PF00076	0.031	RNA recognition motif (RNP domain)
PF00018	166	SH3 domain	PF00018	0.020	SH3 domain
PF00105	144	Zinc finger, C4 type (two domains)	PF00240	0.018	Ubiquitin family
PF00271	133	Helicase conserved C-terminal domain	PF00071	0.012	Ras family
PF00240	133	Ubiquitin family	PF00046	0.011	Homeobox domain
PF00169	117	Pleckstrin homology domain	PF00271	0.011	Helicase conserved C-terminal domain
PF00104	116	Ligand-binding domain of nuclear hormone receptor	PF00105	0.010	Zinc finger, C4 type (two domains)
PF00071	114	Ras family	PF00169	0.010	Pleckstrin homology domain