Research Article

LRRK2 G2385R and R1628P Mutations Are Associated with an Increased Risk of Parkinson’s Disease in the Malaysian Population

Table 2

Summary of published Asian data on G2385R and R1628P.

StudyAsian countrySample sizeResults

G2385R (c.7153G>A), rs34778348
Di Fonzo et al., 2006 [9]Taiwan608 PD, 373 controlsOR 2.24

Fung etal., 2006 [20]Taiwan305 PD, 176 controlsOR 17.00

Farrer et al., 2007 [21]Taiwan410 PD, 335 controlsOR 2.24
Tan et al., 2007 [14]Singapore495 PD, 494 controlsOR 2.14

Tan et al., 2007 [16]Non-Chinese Asian (Malays and Indians)98 PD, 173 controls
66 PD, 133 controls
Malays
OR 1.78
Indians-monomorphic

An et al., 2008 [11]Mainland China600 PD, 334 controlsOR 3.94

Funayama et al., 2007 [10]Japan448 PD, 457 controlsOR 2.60

Zabetian et al., 2009 [7]Japan601 PD, 1,628 controlsOR 1.96

Miyake et al., 2010 [22]Japan229 PD, 358 controlsOR 2.06

Kim et al., 2010 [12]Korea923 PD, 422 controls
119 YOPD
814 LOPD
Combined
OR 1.83
YOPD
OR 2.28
LOPD
OR 1.81

Ross et al., 2011 [19]AsianTaiwanese
369 PD, 300 controls
Korean
844 PD, 587 controls
Japanese
173 PD, 95 controls
Combined
1,386 PD, 982 controls
OR 1.62
* value not stated
OR 1.87
* value not stated
OR 1.44
* value not stated
OR 1.73

Current study Malaysia695 PD, 507 controlsOR 2.22

R1628P(c.4883G>C), rs33949390
Mata et al., 2005 [15]Europe, Asia, and North America100 PD probands with family history of parkinsonism,
300 controls
MAF 0.01

Lu et al., 2008 [18]Taiwan834 PD, 543 controlsOR 2.13

Tan et al., 2008 [16]Singapore246 PD, 243 controlsOR 2.5

Tan et al., 2008 [23]Non-Chinese Asian (Malays and Indians)132 PD, 160 controls
60 PD, 105 controls
OR 0.61
Indians-monomorphic

Ross et al., 2008 [13]Taiwan, SingaporeWu RM
484 PD, 341 controls
Wu YR
345 PD, 316 controls
EK Tan
250 PD, 250 controls
Combined
1079 PD, 907 controls
OR 2.15
OR 1.39
OR 2.20

OR 1.84

Zabetian et al., 2009 [7]Japanese631 PD, 320 controlsMonomorphic

Yu et al., 2009 [24]Mainland China328 PD, 300 controlsOR 2.68

Zhang et al., 2009 [25]Mainland China600 PD, 459 controlsOR 3.14

Kim et al., 2010 [12]Korea384 PD, 384 controlsOR 2.98

Pulkes et al., 2011 [17]Thai154 PD, 156 controlsOR 3.25

Ross et al., 2011 [19] AsianTaiwanese
(369 PD, 300 controls)
OR 0.56
Korean
(844 PD, 587 controls)
OR 2.47
Japanese
(173 PD, 95 controls)
Monomorphic
Combined
(1,386 PD, 982 controls)
OR 0.62

Current study Malaysian695 PD, 507 controlsOR 1.23