Benchmarking B-Cell Epitope Prediction with Quantitative Dose-Response Data on Antipeptide Antibodies: Towards Novel Pharmaceutical Product Development

Figure 4

Antibody-dependent enhancement of infection as mathematically modeled for HIV in cultures of U937 monocytoid cells [17] in the limit of low multiplicity of infection. Relative number of infected cells is set to unity (represented by dotted baseline) for zero antibody concentration. Curves are shown for two different antibody affinity levels expressed in legend as association constant (and equivalent dissociation constant in parentheses). Enhancement could be expressed as a fraction of the maximum enhancement (i.e., at the peak of the curve), with zero enhancement at zero antibody concentration.