The Role of Histone Ubiquitination during Spermatogenesis

Figure 1

Indicated is the timeline of mouse spermatogenesis. Major stages of spermatogenesis, and cell types were shown in the diagram. Major ubiquitin ligases, including Huwe1, RNF8, were expressed in different stages of spermatogenesis. Histone ubiquitin ligase plays important roles in ubiquitination of histone and its variants, thus implicating in diverse stages of spermatogenesis. Dpp means postnatal days to show development stage of normal spermatogenesis. From 3 to 6 days, gonocyte is the major type in seminiferous tube, from postnatal 6 (6 dpp), leptotene spermatocyte appears, while during 10 dpp to 20 dpp, DDR and MSCI were observed in spermatocyte, histone removal begins from 18.8 dpp to the final stage; spermiogenesis begins from 25.3 to 34.5 dpp with drastic morphology change to form the mature sperm.