The Role of Histone Ubiquitination during Spermatogenesis

Table 1

Current known histone ubiquitin liagses with KO mice model.

Histone Ubiquitin Enzyme	Target	Blocking stage	KO phenotype
HR6B		Spermatid	Infertile [29]
UBC4-t		Spermatocyte	Fertile [30]
Huwe1	H2A, H2B, H3, H4	Spermatogonia	Infertile (unpublished data)
UBR2	H2A	Meiosis	Infertile [31]
RNF8	H2A, H2B	Spermatocyte spermatid	Infertile [32]
Rnf168	H2A	Meiosis	Infertile [33]