Review Article
The Role of Histone Ubiquitination during Spermatogenesis
Table 1
Current known histone ubiquitin liagses with KO mice model.
| Histone Ubiquitin Enzyme | Target | Blocking stage | KO phenotype |
| HR6B | ā | Spermatid | Infertile [29] | UBC4-t | ā | Spermatocyte | Fertile [30] |
| Huwe1 | H2A, H2B, H3, H4 | Spermatogonia | Infertile (unpublished data) | UBR2 | H2A | Meiosis | Infertile [31] | RNF8 | H2A, H2B | Spermatocyte spermatid | Infertile [32] | Rnf168 | H2A | Meiosis | Infertile [33] |
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