Inhibition of Brain Swelling after Ischemia-Reperfusion by β-Adrenergic Antagonists: Correlation with Increased K⁺ and Decreased Ca²⁺ Concentrations in Extracellular Fluid

Table 1

Brain water content in MCAO model with and without reperfusion.

	No reperfusion		8 hr reperfusion
	Left hemisphere	Right hemisphere	Left hemisphere	Right hemisphere
Control	77.58 ± 0.20 ( = 5)	78.05 ± 0.29 ( = 5)	77.34 ± 0.18 ( = 3)	77.32 ± 0.14 ( = 3)
Ischemia 3 h	77.25 ± 0.16 ( = 5)	78.14 ± 0.25 ( = 5)	77.97 ± 0.17 ( = 8)	81.28 ± 0.34^* ( = 8)

Water content was calculated as (wet weight − dry weight)/wet weight × 100% in rats where MCAO had been performed on the right side. In control rats no significant change occurred with or without reperfusion. In animals with MCAO in the right hemisphere a small apparent increase in water content in this hemisphere after 3 hr of ischemia was not statistically significant, whereas a larger increase after reperfusion marked with * was significant ( < 0.05). It was also significantly different ( < 0.05) from the small apparent increase without reperfusion.