Research Article
Development and Characterization of In Situ Oral Gel of Spiramycin
Table 1
Preparation of spiramycin in situ oral gel using different concentrations of calcium chloride, sodium citrate, and sodium bicarbonate.
| Quantity in 100 mL (concentration in % w/v) | S. number | Ingredients | F-1 | F-2 | F-3 | F-4 | F-5 | F-6 | F-7 | F-8 |
| 1 | Drug | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 2 | Calcium chloride | 0.050 | 0.075 | 0.10 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 3 | Sodium citrate | 0.25 | 0.30 | 0.35 | 0.40 | 0.45 | 0.5 | 0.5 | 0.5 | 4 | Sodium alginate | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 5 | HPMC | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | 6 | Sodium bicarbonate | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 0.5 | 1.0 | 2.0 |
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