Development and Characterization of In Situ Oral Gel of Spiramycin

Table 1

Preparation of spiramycin in situ oral gel using different concentrations of calcium chloride, sodium citrate, and sodium bicarbonate.

Quantity in 100 mL (concentration in % w/v)
S. number	Ingredients	F-1	F-2	F-3	F-4	F-5	F-6	F-7	F-8
1	Drug	5.00	5.00	5.00	5.00	5.00	5.00	5.00	5.00
2	Calcium chloride	0.050	0.075	0.10	0.15	0.15	0.15	0.15	0.15
3	Sodium citrate	0.25	0.30	0.35	0.40	0.45	0.5	0.5	0.5
4	Sodium alginate	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5
5	HPMC	0.8	0.8	0.8	0.8	0.8	0.8	0.8	0.8
6	Sodium bicarbonate	1.5	1.5	1.5	1.5	1.5	0.5	1.0	2.0