Research Article
Development and Characterization of In Situ Oral Gel of Spiramycin
Table 2
Preparation of spiramycin in situ oral gel using different concentrations of sodium alginate and HPMC.
| | Quantity in 100 mL (concentration in % w/v) | | S. number | Ingredient | F-9 | F-10 | F-11 | F-12 | F-13 | F-14 | F-15 | F-16 |
| | 1 | Drug | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 | | 2 | Calcium chloride | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | | 3 | Sodium citrate | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | | 4 | Sodium alginate | 2.0 | 2.0 | 2.0 | 2.5 | 2.5 | 2.5 | 3.0 | 3.0 | | 5 | HPMC | 0.3 | 0.3 | 0.3 | 0.6 | 0.6 | 0.6 | 0.9 | 0.9 | | 6 | Sodium bicarbonate | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 |
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