Development and Characterization of In Situ Oral Gel of Spiramycin

Table 3

pH, drug content, in vitro gelation, and floating studies of different formulations.

Formulations	pH	Drug content (percentage)	Gelling studies	Floating lag time; (seconds)	Duration of floating; (hours)
F-9	7.54 ± 0.010	84 ± 0.26	++	18.0	>12
F-10	7.56 ± 0.004	87 ± 0.22	++	15.0	>12
F-11	7.55 ± 0.010	83 ± 0.14	++	13.0	>12
F-12	7.53 ± 0.002	86 ± 0.20	+++	21.0	>12
F-13	7.58 ± 0.12	84 ± 0.12	+++	15.0	>12
F-14	7.51 ± 0.002	83 ± 0.20	+++	10.0	>12
F-15	7.56 ± 0.008	85 ± 0.14	++	12.0	>12
F-16	7.54 ± 0.006	87 ± 0.10	++	16.0	>12

(++) Gelation immediate remains for 12 hours.
(+++) Gelation immediate remains for more than 12 hours.