Research Article
Development and Characterization of In Situ Oral Gel of Spiramycin
Table 3
pH, drug content, in vitro gelation, and floating studies of different formulations.
| Formulations | pH | Drug content (percentage) | Gelling studies | Floating lag time (seconds) | Duration of floating (hours) |
| F-9 | 7.54 ± 0.010 | 84 ± 0.26 | ++ | 18.0 | >12 | F-10 | 7.56 ± 0.004 | 87 ± 0.22 | ++ | 15.0 | >12 | F-11 | 7.55 ± 0.010 | 83 ± 0.14 | ++ | 13.0 | >12 | F-12 | 7.53 ± 0.002 | 86 ± 0.20 | +++ | 21.0 | >12 | F-13 | 7.58 ± 0.12 | 84 ± 0.12 | +++ | 15.0 | >12 | F-14 | 7.51 ± 0.002 | 83 ± 0.20 | +++ | 10.0 | >12 | F-15 | 7.56 ± 0.008 | 85 ± 0.14 | ++ | 12.0 | >12 | F-16 | 7.54 ± 0.006 | 87 ± 0.10 | ++ | 16.0 | >12 |
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(++) Gelation immediate remains for 12 hours. (+++) Gelation immediate remains for more than 12 hours.
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