Modulation of c-Fos and BDNF Protein Expression in Pentylenetetrazole-Kindled Mice following the Treatment with Novel Antiepileptic Compound HHL-6
Figure 5
(a) Images of the BDNF immunoreactivity in cortical region of normal and kindled mice brains. A marked increase in the BDNF immunofluorescence was observed in the PTZ-kindled control brain section. In comparison to the PTZ-control group, the immunoreactivity of BDNF in the brain sections of the kindled animals treated with HHL-6 and diazepam was markedly reduced. (b) Graphical representation of the level of expression of immunohistochemically detected BDNF. The captured immunoimages were analyzed by ImageJ software. In comparison to the normal control group (), the PTZ-control animals showed a significant increase in the BDNF staining intensity (, *). In contrast, BDNF expression in the kindled animals treated with HHL-6 (, **) and diazepam (, ) declines significantly.
