Modulation of c-Fos and BDNF Protein Expression in Pentylenetetrazole-Kindled Mice following the Treatment with Novel Antiepileptic Compound HHL-6

Table 3

Effect of HHL-6 on the duration and inhibition of seizure in scPTZ-induced seizure in mice.

Group	Dose	Onset of jerks (sec)	Rearing and falling (sec)
GI (Normal control)	0.2 mL/kg	0	0
GII (PTZ-control)	90 mg/kg	190	640
GIII (Diazepam + PTZ)	7.5 mg/kg	0	0
GIV (HHL-6 + PTZ)	20 mg/kg	460	0

The HHL-6 and diazepam were injected intraperitoneally 30 min before the administration of subcutaneous pentylenetetrazole (90 mg/kg) in their respective groups. Values are presented as mean for the duration of tonic seizure for 6 mice.