MicroRNAs: Promising New Antiangiogenic Targets in Cancer

Table 1

Angiogenic miRNAs related to cancer and their targets.

miRNA	Role	Function	Targets	Reference
Dicer	Function loss	Maturation of microRNAs	miRNAs	[56, 57]; [58, 60, 61]
miR-126	Proangiogenic	Regulates the response of endothelial cells to VEGF	SPRED-1, PIK3R2, VECAM-1,	[64, 68, 71]
miR-221/222	Antiangiogenic and proangiogenic	Inhibitor of SCF	C-KIT, eNOS, p27	[73]; [61]; [74]
miR-17-92 cluster	Proangiogenic and antiangiogenic	Regulation of vascular integrity	THBS1, p21, S1P, JAK1; Flk-1 (VEGFR-2)	[83]; [86]; [88]
let-7f; miR-27b	Proangiogenic	↑EC-mediated angiogenesis	*ND	[75]
miR-214	Antiangiogenic	Tubular sprouting	Quaking	[89]
miR-93	Proangiogenic	Enhanced endothelial cell activity	LATS2	[90]
miR-210	Proangiogenic	Endothelial cell migration and formation of capillaries	Ephrin-A3	[97]
miR-20b	Antiangiogenic	Decreases levels of HIF1A and VEGF	VEGF, HIF-1α	[102, 103]
miR-21	Antiangiogenic	Induction of tumour angiogenesis, confers resistance to hypoxia	PTEN,; PDCD4, Sprouty1	[104]; [105]
miR-200 family	Antiangiogenic	Epithelial-mesenchymal transition	ETS-1	[109]
miR-200c	Antiangiogenic	Epithelial-mesenchymal transition	VEGFR-2	[110]
miR-107	Antiangiogenic	Hypoxia signalling	HIF-1β	[111]
miR-519c	Proangiogenic	Depletion of tumour angiogenesis	HIF-1α	[112]
miR-424	Proangiogenic and antiangiogenic	Destabilization of the E3-ligase assembly, increasing HIF-1α levels	CUL-2; VEGF; VEGFR-2; FGFR-1	[113]; [117]
miR-15a	Antiangiogenic	Control of the cell cycle, apoptosis, proliferation, and angiogenesis	BCL-2; VEGF-A	[116]
miR-16	Antiangiogenic	Controls VEGF expression and induces cell apoptosis	VEGF; VEGFR-2; FGFR-1; BCL-2; VEGF-A	[117]; [116]
miR-378	Proangiogenic	Cell survival and tumour growth	SUFU and FUS-1	[114, 119]
miR-296	Proangiogenic	Promotes angiogenesis by increasing levels of proangiogenic growth factor receptors	HGS	[120]
miR-199a	Antiangiogenic	Suppresses tumour angiogenesis via the HIF-1α/VEGF pathway	HER3	[121]
miR-125b	Antiangiogenic	Suppresses tumour angiogenesis via the HIF-1α/VEGF pathway	HER2; HER3	[121]
miR-361-5p	Antiangiogenic	Cancer development and progression	VEGF A	[122]
miR-1/206	Antiangiogenic	Regulation of VegfA expression	VEGF A	[124]
miR-10b	Proangiogenic	Regulation of endothelial cell division and migration	HOXD10, FLT1	[123]
miR-196b	Proangiogenic	*ND	*ND	[63]
miR-503	Antiangiogenic	Overexpression reduces tumour angiogenesis	FGF2, VEGFA	[130]
miR-128	Antiangiogenic	Decreases cell proliferation, tumour growth, and angiogenesis	P70S6K1	[131]
mir-145	Antiangiogenic	Inhibition of tumour growth and angiogenesis	P70S6K1	[132]
miR-130a	Proangiogenic	Increases angiogenesis by targeting GAX and HOXA5 (antiangiogenic genes)	GAX, HOXA5	[133]
miR-132	Proangiogenic	Increases Ras activity	p120RasGAP	[134]
miR-26a	Antiangiogenic	Suppresses tumour growth and metastasis	PIK3C2α; HGF	[135]; [136]

ND: not described.