The Effect of Hypoxia on the Stemness and Differentiation Capacity of PDLC and DPC
Figure 3
Effect of hypoxia on the mRNA expression levels of Oct-4, Sox2, and c-Myc in PDLCs and DPCs. The mRNA expressions of Oct-4, Sox2, and c-Myc in PDLCs significantly increased after exposure to 2% O2 for 24 h (a) till 7 days (b) (*). Western blotting analysis further confirmed the result in protein level (c). The expressions of Oct-4, Sox2, and c-Myc in DPCs cultured in hypoxia showed a similar pattern ((d)–(f)) (*).
