Antiproliferative Activity of Hamigerone and Radicinol Isolated from Bipolaris papendorfii

Table 1

IC₅₀ of hamigerone and radicinol in different cell lines.

Cell line	IC50 in M (±SD)
	Hamigerone	Radicinol	Gemcitabine	Flavopiridol
Panc-1 (pancreatic)	1.9 ± 0.92	10.50 ± 1.4	0.38 ± 0.04	0.62 ± 0.05
ACHN (renal)	4.3 ± 0.78	14.28 ± 1.8	0.78 ± 0.07	0.91 ± 0.11
Calu1 (lung)	2.91 ± 1.1	12.60 ± 0.87	0.98 ± 0.11	0.79 ± 0.19
H460 (non-small cell lung)	2.42 ± 0.63	21.6 ± 3.2	1.23 ± 0.23	0.82 ± 0.09
HCT116 (colon)	2.91 ± 0.87	25 ± 2.9	1.15 ± 0.21	0.73 ± 0.08
MCF10A (normal breast epithelium)	>30	>30	>10	>10

IC₅₀ values of hamigerone and radicinol in different cancer cells at 48 h. The cells were exposed to different concentrations at end of 48 h; cytotoxicity was measured using live cell dehydrogenase assay.