Variations in KIR Genes: A Study in HIV-1 Serodiscordant Couples

Table 5

KIR genes association with viral load and CD4 count in HSPs by linear regression (𝑛=47).

KIR	Frequency (𝑁=47); %	HIV-1 viral load; (log10)	𝛽	𝑃	Median CD4+; T cell; count (cells/μL)	𝛽	𝑃
2DL1	80.8	3.91	−0.170	0.287	322	0.251	0.873
2DL2	78.2	3.94	−0.250	0.115	304	0.218	0.161
2DL3	72.3	3.86	−0.088	0.582	331	−0.074	0.638
2DL4	85.1	3.76	0.027	0.865	328	−0.056	0.721
2DL5 A	59.5	3.48	0.227	0.153	304	0.126	0.420
2DL5 B	74.6	3.63	0.159	0.321	317	0.066	0.672
2DS1	63.8	3.27	0.404	0.009*	341	−0.127	0.417
2DS2	85.1	3.79	−0.034	0.835	318	0.072	0.647
2DS3	63.8	3.74	0.034	0.835	340	−0.174	0.266
2DS4-Nor	85.1	3.55	0.163	0.307	314	−0.055	0.726
2DS4-Del	80.8	3.99	−0.336	0.032*	295	−0.196	0.207
2DS5	74.4	3.59	0.188	0.238	322	0.018	0.911
3DL1	78.7	3.99	−0.287	0.069	342	−0.185	0.235
3DL2	95.7	3.82	−0.184	0.250	334	−0.258	0.095
3DL3	93.6	3.79	−0.074	0.644	322	0.037	0.812
3DS1	72.3	3.58	0.218	0.172	327	−0.033	0.835
2DP1	93.6	3.74	0.086	0.595	324	−0.011	0.943
3DP1*003	82.9	3.70	0.105	0.512	333	0.116	0.458
3DP1*001-004	27.6	3.64	0.060	0.707	299	0.082	0.602

HSPs: HIV seropositive spouses; OR: odds ratio; CI: confidence interval; ^∗𝑃 values <0.05 are considered statistically significant; 𝛽: beta value.